When you stop to think about it, casting Pee Wee Herman as the Riddler doesn't seem so weird. Herman (aka Paul Reubens) is one of what's sure to be a ton of guest stars joining the Robot Chicken DC Comics Special, along with Neil Patrick Harris as Two-Face, Alfred Molina as Lex Luthor, Nathan Fillion taking another stab at Green Lantern Hal Jordan, Megan Fox as Lois Lane, Breckin Meyer as Superman, and Seth Green as Batman, Robin, and Aquaman.
The special, which airs this fall, was created in collaboration with DC's CCO Geoff Johns (who's worked regularly with Robot Chicken crew in the past). Presumably, it'll be in the mold of the trilogy of Star Wars specials over the years, with the requisite call-outs to DC Comics history, and possibly even a robot humping a washing machine for good measure. Will that robot be joined by perhaps Metallo? We can only hope.
[Source: TV Guide]